PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4095)
Related Products (4095)
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PROTAC Linkers Isoform Comparison
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NH2-PEG6-C1-Boc
0 ImagesCat. No.: HY-135918CAS No.: 297162-50-6
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1,4-Bis((tetrahydrofuran-2-yl)oxy)butane
0 ImagesCat. No.: HY-W419902CAS No.: 76702-30-2
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4-Mercaptobutanoic acid
0 ImagesCat. No.: HY-W612202CAS No.: 13095-73-3
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Tert-butyl (7-bromoheptyl)(methyl)carbamate
0 ImagesCat. No.: HY-W941702CAS No.: 2734864-63-0
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Methyl (1S,2R)-2-(2-hydroxyethyl)cyclopropane-1-carboxylate
0 ImagesCat. No.: HY-W108822CAS No.: 2165933-01-5
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1'-[(tert-Butoxy)carbonyl]-[1,3'-biazetidine]-3-carboxylic acid
![1'-[(tert-Butoxy)carbonyl]-[1,3'-biazetidine]-3-carboxylic acid](https://file.medchemexpress.com/product_pic/hy-w168255.gif "Click to View 1'-[(tert-Butoxy)carbonyl]-[1,3'-biazetidine]-3-carboxylic acid Product Detail")
0 ImagesCat. No.: HY-W168255CAS No.: 889952-23-2
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TCO4-PEG2-Maleimide
0 ImagesCat. No.: HY-156391CAS No.: 2141981-85-1TCO4-PEG2-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG2-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
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4-(4-Methoxyphenyl)-1-butanol
0 ImagesCat. No.: HY-W007982CAS No.: 52244-70-9
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Boc-NH-C5-NH-Me
0 ImagesCat. No.: HY-W396031CAS No.: 1311458-36-2
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4-(2-Aminoethoxy)benzoic acid hydrochloride
0 ImagesCat. No.: HY-W249270CAS No.: 1050208-10-0
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3,3'-Piperazine-1,4-diyldipropanoic acid
0 ImagesCat. No.: HY-W460315CAS No.: 5649-49-0
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Methyl 2-(4-(hydroxymethyl)phenyl)acetate
0 ImagesCat. No.: HY-W129322CAS No.: 155380-11-3
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(6R,8S,10R,11S,13S,14R)-17-(2-Acetoxyacetyl)-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
![(6R,8S,10R,11S,13S,14R)-17-(2-Acetoxyacetyl)-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate](https://file.medchemexpress.com/product_pic/hy-w711915.gif "Click to View (6R,8S,10R,11S,13S,14R)-17-(2-Acetoxyacetyl)-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate Product Detail")
0 ImagesCat. No.: HY-W711915CAS No.: 91898-32-7
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tert-Butyl 4-(3-bromopropyl)piperazine-1-carboxylate oxalate
0 ImagesCat. No.: HY-W109687CAS No.: 2102410-31-9
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Mal-PEG4-Glu(OH)-NH-m-PEG24
0 ImagesCat. No.: HY-140997CAS No.: 2204309-09-9
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tert-Butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate oxalate(2:1)
![tert-Butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate oxalate(2:1)](https://file.medchemexpress.com/product_pic/hy-w018805.gif "Click to View tert-Butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate oxalate(2:1) Product Detail")
0 ImagesCat. No.: HY-W018805CAS No.: 1788054-69-2
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Boc-NH-PEG2-CH2COOH dicyclohexylamine
0 ImagesCat. No.: HY-W018164CAS No.: 560088-79-1
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3-(4-Bromophenoxy)propanenitrile
0 ImagesCat. No.: HY-W105838CAS No.: 118449-57-3
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Boc-2-(piperazin-1-yl)acetic acid dihydrate
0 ImagesCat. No.: HY-W102047CAS No.: 1049785-94-5
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2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid
0 ImagesCat. No.: HY-W021675CAS No.: 63845-28-3
